药物中晶型，颗粒尺寸及分布检测方案(激光拉曼光谱)

Raman Analysis and Characterisation ofpharmaceuticals RamanSpectroscopy hasimanyyuusefulproperties which can be explored and exploitedin the analysis of pharmaceutical formulations. Highly specific spectral fingerprints. In-situ， rnon contact.and mostimportantly， non destructive analysis. Differentiationnof amorphous andcrystalline phases. Detection of the lattice vibrations of acrystal. Single particle characterisation. Fast and robust raw material analysis. Automated and enclosed operation. These advantages ideally lend the technique tothe analysis of an increasing number ofpharmaceutical products， of especialimportance to the growing regulatory agencies.The applications of Raman in thePharmaceutical Industry ccanbee related todifferent study types ： Polymorph Identification Coatings . Polymers . PDT Studies Component Mapping Molecular Characterisation Phase determination Raw Material Confirmation Polymorphic Form can influence solubilityand efficacy of an active drug as well asprovide patent protection. Yet it may be alteredduringj processing.Dispersion1 of ，acdrugthrough a tablet ensures correct dosage， yetaggregation can occur even though there wereonly subtlee changesinrawmaterialllorprocessing conditions. Raman spectroscopycan give detailed information on these mostimportant properties. SpectraTheereferencespectra(of suchcomponents asan excipient，，lactose anddifferent polymorph forms of an active drug in apharmaceutical formulation can be obtained byRaman spectroscopy. Active form and polymorphs Raman map of 2 components of this sample.Lactose is represented by green and the activedrug by red. (Magnification is higher than themicrograph on the left) ORIBAExplore the future HORIBAJOBIN YVON France ： HORIBA Jobin Yvon S.A.S.， rue de Lille， Villeneuve d'Ascq. Tel：+Fax ： +() Email ： raman@jobinyvon.fr www.jobinyvon.frUsA： HORIBA Jobin Yvon Inc.， Park Avenue， Edison， NJ Tel：+-Fax：+-Email ： raman@jobinyvon.com www.jobinyvon.comJapan ： HORIBA Ltd.， JY Optical Sales Dept.， -- Higashi-kanda， Chiyoda-ku， Tokyo Tel：+() Fax：+() Email： raman@horiba.comGermany： +() Italy： +UK： +()hina： + All HORIBA Jobin Yvon companies were formerly known as Jobin Yvon) /HORIBAExplore the future Raman Spectroscopy has many useful properties which can be explored and exploited in the analysis of pharmaceutical formulations.