上海禾工科学仪器：超高效液相色谱串联质谱测定人尿中的苯二氮卓类药物

文献名： Structural, morphological and optical properties of Bi NPs obtained by laser ablation and their selective detection of L-cysteine 作者： Ramon Gabriel Teixeira Rosaa, Celso de Araujo Duartea , Wido Herwig Schreinera, Ney Pereira Mattoso Filhoa, Arandi Ginane Bezerra Jr.b, Andersson Barisonc, Fernanda Maria Marins Ocamposc a Departamento de Física, Universidade Federal do Paraná Centro Politécnico, CP 19044, 81531-990 Curitiba (PR), Brazil b Departamento Acadêmico de Física, Universidade Tecnológica Federal do Paraná, 80230-901 Curitiba (PR), Brazil c Departamento de Química, Universidade Federal do Paraná Centro Politécnico, CP 19081, 81531-990 Curitiba (PR), Brazil 摘要：In the present work we show the results of the investigation of the properties of bismuth nanoparticles (NPs) obtained by the laser ablation in water. The samples were characterized by various techniques: UV/vis spectroscopy, dynamic light scattering, transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, nuclear magnetic resonance and zeta potential. The NPs were metallic and surface oxidated, exhibiting absorption peak at 257 nm due to the surface plasmon resonance. The interaction between the NPs and various amino acids was studied and revealed a selective sensibility to cysteine on a range of concentration from 80 to 720 μM, which we attribute to a dimerization of cysteine to cystine probably complexed to the nanoparticle surface by electrostatic interactions, leading to the modification of the NP absorption spectrum. 关键词：Bismuth; Nanoparticles; Laser ablation; Cysteine

抗氧化剂是指能防止或延缓食品氧化，提高食品的稳定性和延长贮存期的食品添加剂。GB5009.32-2016《食品安全国家标准 食品中9种抗氧化剂的测定》中采用GPC和C18小柱对食品中9种抗氧化剂进行前处理，该方法回收率低，测试结果不稳定。安谱实验优化了实验方法，用CNW Poly-Sery PSD SPE小柱进行前处理，克服了国标方法的缺点，方法简单，9种抗氧化剂的回收率均在90%以上。

本文参考生态环境部发布的标准《HJ 1261- 2022 固定污染源废气 苯系物的测定 气袋采样/直接进样-气相色谱法》，使用磐诺气相色谱仪，进行苯系物含量测定。

​砷（As）在自然中广泛存在，砷的长期摄入具有一定的健康风险，其毒性作用主要包括生殖发育毒性、神经毒性、免疫毒性，还可诱发人类发生多种癌症，食品中砷的存在及其对人体健康的风险评估仍是今后需要进一步关注和研究的方向。