2020/09/18 10:55
阅读:186
分享:方案摘要:
产品配置单:
布鲁克 timsTOF fleX 组学和成像质谱系统
型号: timsTOF fleX™
产地: 德国
品牌: 布鲁克
面议
参考报价
联系电话
方案详情:
荷兰马斯特里赫特大学的Ron M.A. Heeren教授实验室利用空间定位组学工作流程,对来自于乳腺癌患者的肿瘤组织,进行了蛋白质分子特征的深度研究。
布鲁克timsTOF fleX质谱仪同时具备MALDI成像功能和LC-MS/MS组学分析功能,成功地实现了空间定位组学工作流程中的关键步骤。与传统组学的“整体匀浆方法”相比,空间定位组学充分地考虑到乳腺癌组织中不同的肿瘤亚细胞群之间的差异性,并分别对各个肿瘤亚细胞群体进行了有针对性的、深度的蛋白组分析。以上的众多优点使得空间定位组学为精准地揭示乳腺癌的致病机理奠定了坚实的基础。
下载本篇解决方案:
更多
4D-脂质组学高通量工作流程
Lipid profiling from complex lipid extracts can be a challenging and time consuming task. The high complexity of samples and co-elution of isobaric or isomeric compounds complicate the confident annotation of lipids. The presented 4D-Lipidomics workflow simplifies and streamlines the annotation and validation process using mobility-enhanced MS data.
医疗/卫生
2021/03/05
PASEF应用于COVID-19的高通量定量大规模血浆蛋白质组学研究
However, the dynamic range of protein concentration in these samples poses a challenge for in-depth proteome quantification. PASEF® is a powerful technology for rapid in-depth and sensitive proteome quantification that is also applicable to biofluids like plasma and serum. We combined PASEF with high-throughput gradient settings for the analysis of hundreds of plasma and serum samples and quantified several hundred protein groups routinely in 21- and 47-minute runtimes. The timsTOF Pro coupled with the Evosep One nanoflow UPLC delivers quantitation with median CV less than 20% and quantified more than 70 known biomarkers in a study investigating over 700 COVID-19 serum samples
医疗/卫生
2021/03/05
Proteomic Interrogation of Primary Insulin-secreting Pancreatic β-cells
The combination of integrated ion mobility with warp-speed MS/MS acquisition on the timsTOF Pro paves the way for deep, molecular level understanding of β-cell physiology and potential new targetable pathways for diabetes.
生物产业
2020/09/21
MALDI-2与timsTOF fleX的结合提升药物组织成像灵敏度
最新一代布鲁克timsTOF fleX使用创新的激光后电离MALDI-2技术获得了较传统MALDI 高1-3个数量级的灵敏度。MALDI-2提高了离子产率并降低了离子抑制效应。同时,MALDI-2还可对传统MALDI不能电离的药物和代谢物分子检测和成像,如甾醇、他汀类、激素、维生素、聚糖等生物分子。这种实质性的改进对于DMPK研究尤其重要。
医疗/卫生
2020/09/18