核心参数
仪器种类: 其他检测器
波长范围: 428
测定方式: 法拉第调制
光源: LED
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中科院微生物所
2013/10/20
1
中国农业大学
2011/07/01
1
农科院
2010/02/01
1
IBZ色谱检测器CHIRALYSER的工作原理介绍
色谱检测器CHIRALYSER的使用方法?
IBZCHIRALYSER多少钱一台?
色谱检测器CHIRALYSER可以检测什么?
色谱检测器CHIRALYSER使用的注意事项?
IBZCHIRALYSER的说明书有吗?
IBZ色谱检测器CHIRALYSER的操作规程有吗?
IBZ色谱检测器CHIRALYSER报价含票含运吗?
IBZCHIRALYSER有现货吗?
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四种手性检测器对比
With increasing frequency, new drug candidates being introduced into pharmaceutical drug pipelines are chiral. Often only one enantiomer exhibits the desired biological activity and the other enantiomer may exhibit undesired side effects, thereby making chiral purity an important parameter. The introduction of chiral analysis adds additional complications in drug development. The pharmaceutical industry is constantly striving to streamline processes and improve efficiencies in an effort to move molecules to market quickly. In order to simplify the process of chiral method development, chiral screening can be set up, however a successful chiral screen depends on optimizing two factors: the column and the detector. The following work investigated the second factor and evaluated two types of commercially available chiral detectors for their possible use in chiral method development and screening: polarimeters and circular dichroism (CD) detectors. Linearity, precision, and the limit of detection (LD) of six compounds (trans-stilbene oxide, ethyl chrysanthemate, propranolol, 1-methyl-2- tetralone, naproxen, methyl methionine) on four commercial detectors (three polarimeters and one CD detector) were determined experimentally and the limit of quantitation (LQ) calculated from the experimental LD. Trans-stilbene oxide worked well across all the detectors, showing good linearity, precision and low detection limits. However, the other five compounds proved to be more discriminating and showed that the circular dichroism detector performed better as a detector for chiral screens, over the polarimeters. © 2006 Elsevier B.V. All rights reserved.
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2010/06/24
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