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北京大学--王初

王初
王初 教授

北京大学

【个人简介】

王初教授于2013年12月在北京大学化学学院开展独立研究工作,主要从事化学和计算驱动的功能蛋白质组学相关研究,具体研究方向为(1)运用化学蛋白质组学和化学生物学技术发掘细胞内发生翻译后修饰的氨基酸功能位点(2)利用组学技术分析和鉴定生物活性分子在细胞内的分子靶标及作用位点。(3)研发计算生物学方法,对蛋白组中功能位点进行精准的预测。入职北京大学以来,先后获得国家青年千人计划(2014)、国家杰出青年科学基金(2019)等项目的支持;获得“国际化学生物学学会青年化学生物学家奖”,“药明康德生命化学研究学者奖”等。以通讯作者身份在Nature 、Nature Methods、Nature Chemical Biology 、JACS 、Angew和PNAS 等杂志发表文章。目前担任北京大学前沿交叉学科研究院副院长、化学学院化学生物学系副主任。

精彩报告

2020-12-11 第十一届质谱网络会议(iCMS 2020)
报告:化学驱动的功能蛋白质组学 报名占位
【摘要】 Genome sequencing projects have revolutionized our view of the complexity of prokaryotic and eukaryotic proteomes, however, we are also left with a daunting challenge of functionally annotating these large number of predicted proteins. Experimental chemoproteomic methods, such as activity-based protein profiling (ABPP), have been developed aiming at systematically discovering new functional targets directly from native proteomes. Our research group have developed various ABPP-based strategies to uncover sites of ligand binding, post-translational modifications (PTMs) as well as enzyme catalysis in living cells and tissues. In this talk, I will present some of our recent work in profiling sites of PTMs by a functionally intriguing metabolite named “itaconate”, which has been with strong immunoregulatory and antibacterial activity. Our chemical proteomics studies have revealed a large number of novel and interesting sites of “itaconation” from host macrophages, and provided important clues for further functional characterization of itaconate in mediating host-pathogen interactions.

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