塔望全身体积描记系统WBP

   产品描述             

塔望全身体积描记系统WBP

全身体积描记系统（whole-body plethysmograph，WBP）作为无创检测动物肺功能的一种经典方式，避免了麻醉及气管插管测试对动物造成的损伤，可以对2019-nCov、SARS、MERS感染下的动物肺功能指标进行长期跟踪研究。测量指标如潮气量、分钟通气量、呼气峰值流速、吸气峰值流速、呼吸频率、Penh等。这些数据和临床的数据可以建立直接的相关性，适用于新型冠状病毒、SARS‐CoV和MERS等感染研究。

气道高反应性（Airway hyperresponsiveness，AHR）、气道炎症和可逆的气道阻塞是支气管哮喘的特征。通过动物模型可研究用于防治气道炎症和AHR的方法和受试药物。传统的方式多采用麻醉后气管插管，检测气道阻力和肺顺应性来评估动物气道功能的改变。但这些方法有其局限性，如整体试验中麻醉药物的影响，麻醉深浅和麻醉药物对AHR的神经源和气道炎症的影响，实验人员手术操作技术上的要求和耗时，麻醉或手术后动物存活困难不能长期跟踪研究等因素。

无约束全身体积描记法（whole-body plethysmograph，WBP）可以对清醒自由活动的小动物进行肺功能及气道反应相关的测试，避免了创伤性气管切开术及麻醉的影响，在动物处于自然状态下就可以直接测定其气道反应性。而且每次可以同时检测多只动物。整个实验过程简便快捷，并适合长期跟踪研究。

Therapeutic RDV and LPV/RTV-IFNb improve pulmonary function.

治疗研究，经RDV和LPV/RTV-IFNb治疗后，肺功能改善。

相比对照组，经RDV治疗和LPV + RTVIFNb 低剂量治疗，5天后，动物的EF50减小、PenH减小、Rpef回到基准水平。

数据显示：感染2-15天后的小鼠呼吸功能监测，PR/8比x31感染的小鼠具有更严重的呼吸功能损伤

A：无感染的小鼠和感染9天后的小鼠呼吸信号波形图。

B：呼吸频率（次/min）；C：潮气量（ml）；D：分钟通气量（ml）；E：呼气时间（s）

   产品特点             

塔望全身体积描记系统WBP

适用动物种类:小鼠、幼鼠、大鼠、豚鼠、兔子、犬、猫、小型猪、猴等动物

具有喂食进水装置以方便超长时间的实验

测量通道：1-64通道

自动化偏流控制功能

可配置高频振荡雾化给药系统

特殊的减噪结构设计，可有效减少环境变化造成的干扰

可进行偏流仪降噪，提高信号的信噪比，减少系统噪音

自动校准功能，同对描记器进行全自动标定，减少手工操作引入的误差，提高实验效率

支持外接氮气或其它气体，完成低氧实验

具有分析软件，数据可保存至excel或txt格式

软件可自动切换多达四通道不同的气体，也可通过外置控制器操作

   可选功能            

塔望全身体积描记系统WBP

温湿度检测功能

咳嗽检测功能

自动活动状态静脉注射给药

心电、体温、活动度遥测

同步视频采集和记录

其它功能可定制

   检测参数             

塔望全身体积描记系统WBP

Ti：吸气时间（s）

Te：呼气时间（s）

PIF：最大吸气流速（ml/s）

PEF：最大呼气流速（ml/s）

Volbal:呼吸比

F：呼吸频率（次/min）

Vt：潮气量（ml）

Mv：分钟通气量（ml）

AV：累积体积（ml）

EF50：呼出50%气量时对应的呼气流速（ml/s）

EIP:吸气峰值压力（仅在侵入式法测量时有效）

EEP：呼气峰值压力（仅在侵入式法测量时有效）

TR:松弛时间

PenH：增强呼气间歇（enhanced pause）

   选型规格             

塔望全身体积描记系统WBP

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