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Spectra S/TEM 扫描透射电子显微镜型号： Spectra S/TEM -
Hitachi日立CT15RE台式离心机型号： CT15RE -
Hitachi日立超速离心机CP70ME型号： CP70ME -
电热鼓风干燥箱型号： CS101-ABN -
Agilent GC 8890 气相色谱系统型号： 8890 GC -
上海辰华电化学工作站CHI760E型号： CHI760E -
Quantum Design-FusionScope扫描电镜——SEM+AFM二合一显微镜型号： FusionScope -
ASML 光刻机 1460K型号： ASML 光刻机 1460K -
珀金埃尔默PerkinElmer NexION 1100/1000G ICP-MS型号： NexION 1100/1000G ICP-MS
获取电话Quantity size:
0.2ml
Concentration:
1mg/ml DNA聚合酶α抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1.DNA聚合酶α抗体 The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase DNA聚合酶α抗体delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes.
Also known as:
DNA聚合酶α抗体DNA polymerase alpha 1 catalytic subunit; DNA polymerase alpha catalytic subunit; DNA polymerase alpha catalytic subunit p180; DNA polymerase alpha p180 subunit; DPOLA_HUMAN; P180; p180 subunit; POLA; POLA1; Polymerase (DNA directed), alpha 1, catalytic subunit; Polymerase (DNA-directed), alpha (70kD).
Specificity:
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Rabbit Polyclonal IgG, affinity purified by Protein A.
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Reacts with: Human, Mouse, Rat, Dog, Horse, Rabbit, .
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Immunogen: KLH conjugated synthetic peptide derived from human DPOLA/DNA polymerase alpha.
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DNA聚合酶α抗体Predicted Molecular Weight: 161kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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